Hotels in Santee

Q: What accommodations do travelers like in Santee?

Guests like Baymont by Wyndham Santee , Tru By Hilton Santee and Comfort Inn & Suites Santee .

Free cancellation options if plans change

Unlock travel rewards with One Key

Save more with Member Prices

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Where to stay in Santee?

ⓘ Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Santee on Hotels.com. These Santee hotels consistently deliver on comfort, location, and value. Last updated on June 5, 2026.

Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi

Baymont by Wyndham Santee

Santee

$79 nightly

Jun 25 - Jun 26

Total with taxes and fees

Hampton Inn Santee-I-95

Santee

$119 nightly

Jun 21 - Jun 22

Total with taxes and fees

Fairfield Inn & Suites by Marriott Santee

Santee

$134 nightly

Jun 14 - Jun 15

Total with taxes and fees

Best Western Plus Santee Inn

Santee

$110 nightly

Jun 21 - Jun 22

Total with taxes and fees

Tru By Hilton Santee

Santee

$106 nightly

Jun 14 - Jun 15

Total with taxes and fees

Holiday Inn Santee by IHG

Santee

$99 nightly

Jun 14 - Jun 15

Total with taxes and fees

Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes

Comfort Inn & Suites Santee

Santee

$97 nightly

Jun 28 - Jun 29

Total with taxes and fees

In-room safe, iron/ironing board, free WiFi, bed sheets

Travelodge by Wyndham Santee

Santee

$62 nightly

Jun 25 - Jun 26

Total with taxes and fees

Ramada by Wyndham Santee I-95

Santee

$72 nightly

Jul 5 - Jul 6

Total with taxes and fees

Red Roof Inn Santee

Santee

$62 nightly

Jun 25 - Jun 26

Total with taxes and fees

Room, 2 Double Beds, Accessible, Non Smoking (Mobility) | Bathroom | Combined shower/tub, free toiletries, hair dryer, towels

Super 8 by Wyndham Santee/I-95

Santee

$63 nightly

Jun 25 - Jun 26

Total with taxes and fees

Quality Inn & Suites Santee I-95

Santee

$60 nightly

Jun 28 - Jun 29

Total with taxes and fees

Desk, iron/ironing board, free WiFi, bed sheets

Econo Lodge Santee

Santee

$64 nightly

Jul 5 - Jul 6

Total with taxes and fees

Spark by Hilton Orangeburg

Orangeburg

$100 nightly

Jul 5 - Jul 6

Total with taxes and fees

Room, 1 King Bed, Non Smoking | Premium bedding, desk, laptop workspace, iron/ironing board

Days Inn by Wyndham St George

St. George

$84 nightly

Jun 14 - Jun 15

Total with taxes and fees

Desk, laptop workspace, iron/ironing board, free WiFi

SureStay Hotel by Best Western Manning

Manning

$85 nightly

Jun 21 - Jun 22

Total with taxes and fees

Tru by Hilton Orangeburg

Orangeburg

$114 nightly

Jun 22 - Jun 23

Total with taxes and fees

Fairfield Inn by Marriott Orangeburg

Orangeburg

$116 nightly

Jun 7 - Jun 8

Total with taxes and fees

Peach Tree Inn

St. George

$65 nightly

Jul 5 - Jul 6

Total with taxes and fees

Hampton Inn Manning

Manning

$122 nightly

Jun 20 - Jun 21

Total with taxes and fees

View all properties

Get last-minute hotel deals in Santee and save more

Sign in to unlock great savings.

Best Western Plus Santee Inn

Santee

We have 1 left at

$148 nightly

Total with taxes and fees

Fairfield Inn & Suites by Marriott Santee

Santee

We have 3 left at

$174 nightly

Total with taxes and fees

Comfort Inn & Suites Santee

Santee

$155 nightly

Total with taxes and fees

Best Western Plus Santee Inn

Santee

$148 nightly

Total with taxes and fees

Fairfield Inn & Suites by Marriott Santee

Santee

We have 1 left at

$179 nightly

Total with taxes and fees

Comfort Inn & Suites Santee

Santee

$150 nightly

Total with taxes and fees

Best Western Plus Santee Inn

Santee

$128 nightly

Total with taxes and fees

Fairfield Inn & Suites by Marriott Santee

Santee

We have 1 left at

$161 nightly

Total with taxes and fees

Comfort Inn & Suites Santee

Santee

$136 nightly

Total with taxes and fees

2 Mi to Lake Marion! Pet-friendly Home w/ Yard

Santee

We have 1 left at

$304 nightly

Total with taxes and fees

Check out pet-friendly hotels in Santee

Baymont by Wyndham Santee

Santee

$79 nightly

Jun 25 - Jun 26

Total with taxes and fees

Fairfield Inn & Suites by Marriott Santee

Santee

$134 nightly

Jun 14 - Jun 15

Total with taxes and fees

View all properties

Go beyond your typical stay in Santee

Pet friendly

Pool

Our prices for hotels in Santee are cheapest in March

Top landmarks in Santee

Santee State Park

4.0/5 (219 reviews)

Santee State Park is 2.7 mi (4.4 km) from central Santee, why not stop by during your stay.

See properties

Learn more about Santee

Tee off at championship golf courses or cast a line in Lake Marion's fish-rich waters where locals claim the bass practically jump into your boat. The Santee National Wildlife Refuge offers hiking trails where alligators sun themselves with reptilian nonchalance. Interstate 95 crosses the lake on a causeway that provides views worth pulling over for (safely, of course). Santee State Park delivers lakeside tranquility that makes visitors forget their phones exist. This resort town punches well above its weight with dining options that range from fresh-caught catfish to surprisingly sophisticated fare. The recent addition of the Santee Cooper Regional Water System has locals buzzing about growth while still cherishing their small-town atmosphere.

See all hotels in Santee

Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina

Check out reviews of Santee hotels guests love

Hampton Inn Santee-I-95

10/10 Excellent

"Very clean and quiet. A great place to stop on our way north."

Quality Inn & Suites Santee I-95

4/10 Poor

"The towels had dirt stains on them, there was hair everywhere in the bathroom, stuck to shower walls, on floor, etc…The guy that checked me in wasn’t helpful and had an attitude. It looked like dried blood on the stairwell, which was nasty, dirty. I won’t be back, too many better choices less than a mile away."

Baymont by Wyndham Santee

4/10 Poor

"My room was miskeyed and someone walked into my room because they didn’t change the original room in the computer and so I was terrified the rest of the night and I finally fell asleep in at 6:30 AM. The dumpster guy came right outside of my door. Outside entry. It did not go well. Breakfast unappealing."

Best Western Plus Santee Inn

10/10 Excellent

"My regular stop driving back to Florida from NYC . Easy access off 95 back ride up to your room. Rooms are spotless very nice restaurant on the property other options nearby Pizza Hut, Waffle House, Starbucks, huddle house and the number of others. Breakfast is excellent coffee 24 hours eggs bacon waffles cereals. Staff is always welcoming. Stayed in room 134 last night the young lady, who is cleaning the rooms spoke to her this morning very friendly and just a sweet person. I I have stopped and left many hotels during the years driving up to New York and back this hotel has made my stop coming back consistent and just perfect. Wouldn't stay any place else and neither should you"

Frequently asked questions

How much does a hotel room cost in Santee?

You can find top hotels in Santee from $67 with options to suit your budget and needs. Baymont by Wyndham Santee is one low-cost option that's popular with our travelers. If you're looking for an affordable hotel in Santee that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at Santee hotels?

Discover great deals on Santee hotel stays with Hotels.com. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on Santee hotels.

Can I book Santee hotels with free cancellation?

In order to book a refundable Santee hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". Most hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What are some top pet-friendly hotels in Santee?

Our travelers' top pet-friendly hotels in Santee include:

Holiday Inn Santee by IHG: A hotel with a guest rating of 8.2 out of 10

You can also use the "Amenities" filter in your search on Hotels.com and check "Pet friendly" to discover more pet-friendly hotels in Santee.

What are the top Santee hotels with a pool?

For a little extra luxury, discover some of the best Santee hotels with a pool. Holiday Inn Santee by IHG is a great hotel with an indoor pool and a guest rating of 8.2 out of 10. Plus, you can make the most of its restaurant and bar/lounge. To find more stays in Santee with a pool, use the "Amenities" filter on Hotels.com in your search and select "Pool".

What are some of the best Santee hotels with free parking?

If you're exploring by car, finding a great Santee hotel with free parking is a win. Our travelers' favorites include:

Fairfield Inn & Suites by Marriott Santee: A hotel with an average guest rating of 9.8 out of 10
Hampton Inn Santee-I-95: A hotel with an average guest rating of 9.6
Tru By Hilton Santee: A hotel with an average guest rating of 9.2

What are some popular hotels in central Santee?

If you're looking for hotels in central Santee, check out Holiday Inn Santee by IHG. Travelers love Holiday Inn Santee by IHG for its location, as well as the indoor pool, restaurant and bar/lounge this hotel offers.

What accommodations do travelers like in Santee?

Guests like Baymont by Wyndham Santee, Tru By Hilton Santee and Comfort Inn & Suites Santee.

Can I book refundable accommodations in Santee?

If you want the flexibility to change your plans to Santee, most accommodations provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where should I stay in Santee if I'm looking for a reasonably priced accommodation?

A few inexpensive options worth considering are Baymont by Wyndham Santee, Tru By Hilton Santee and Comfort Inn & Suites Santee.

Where can I stay in Santee if I want a vacation rental instead of a hotel?

Browse 8 vacation homes on our site. You also might want to book one of 101 condos for your trip.

What will the weather in Santee be like during my vacation?

July and August are typically the warmest months in Santee when the average temp is 79°F. January and February are the coldest months when the average temperature is 52°F. August and July are the months with the most rain.

Find out more about Santee

Santee: Where Tranquil Waters Meet Scenic Wonders

Nestled between Lake Marion and the serene landscapes of Santee State Park, Santee, South Carolina, is a hidden gem for nature lovers and outdoor enthusiasts. This charming destination offers fishing, hiking, and birdwatching, making it perfect for a peaceful getaway. Visitors can unwind at friendly local hotels and explore the picturesque lakeside, where stunning sunsets create unforgettable memories. With its blend of natural beauty and Southern hospitality, Santee invites travelers to experience the tranquility of the South while enjoying recreational adventures and serene surroundings. Discover the charm of Santee—your perfect escape awaits.

Discover great hotels near Santee

Santee, South Carolina offers a range of hotel accommodations, from cozy inns to spacious suites. Visitors can find friendly places to stay that cater to various budgets and preferences, all while being close to the area's natural beauty and outdoor activities. Enjoy a comfortable stay in this charming town. Here are some of our travelers' favorite hotels near Santee:

Days Inn by Wyndham SummertonOpens in a new window: Days Inn by Wyndham Summerton is a budget-friendly hotel that caters to leisure travelers seeking a comfortable and inviting stay. This property excels in providing essential amenities, ensuring a delightful experience. With a welcoming environment and thoughtful offerings, Days Inn by Wyndham Summerton stands out for its family-friendly accommodations, including free cribs. Positive sentiments highlight the overall comfort and convenience, making it a perfect choice for those looking for a relaxing getaway in Santee.
Days Inn by Wyndham Orangeburg SouthOpens in a new window: Days Inn by Wyndham Orangeburg South is a charming budget-friendly motel designed for leisure travelers seeking comfort and simplicity. Known for its clean rooms and excellent service, this property provides a warm atmosphere that enhances the travel experience. Guests appreciate the well-maintained facilities and the welcoming ambiance. With a focus on providing a pleasant stay, Days Inn by Wyndham Orangeburg South is ideal for those who value a straightforward yet enjoyable lodging experience.
Palmetto InnOpens in a new window: Palmetto Inn is a delightful budget-friendly motel, perfect for leisure travelers looking for a cozy and inviting atmosphere. This property is recognized for its pet-friendly policy, allowing guests to enjoy their stay without leaving their furry companions behind. The accommodations are well-kept, providing a relaxing retreat for all. Positive reviews reflect satisfaction with the overall experience, making Palmetto Inn a great option for those seeking comfort and convenience in Santee.

Where to stay near Santee

Some great areas to stay in when visiting Santee, South Carolina, are Summerton, Eutawville, and Holly Hill. Summerton offers excellent golf and budget-friendly accommodations, while Eutawville features unique points of interest and outdoor activities. Holly Hill provides a charming small-town atmosphere. For first-time visitors, Summerton is the best choice due to its diverse recreational options.

SummertonOpens in a new window: Summerton is a charming spot for travelers who love golf and outdoor activities. Nestled near Lake Marion, it offers beautiful landscapes and plenty of opportunities to hit the links at local golf courses. The serene environment is perfect for a relaxing getaway, with fishing and boating options readily available for those looking to enjoy the lake. Plus, its small-town feel gives you a taste of Southern hospitality, making it easy to unwind and explore the local shops and parks.
EutawvilleOpens in a new window: Eutawville is an inviting destination that boasts a rich history and a close-knit community vibe. Known for its scenic views and proximity to Lake Marion, it’s a great place for those who enjoy fishing, kayaking, and exploring nature trails. The town's quaint shops offer unique finds, and local events often bring the community together, providing a glimpse into the area's culture. Whether you're looking to relax by the water or dive into local traditions, Eutawville has something special to offer.
Holly HillOpens in a new window: Holly Hill is a delightful place for visitors seeking a peaceful retreat amid nature. This small town features beautiful parks and outdoor spaces, making it perfect for leisurely strolls or picnics. The friendly community often hosts local festivals and events, giving travelers a chance to mingle with residents and experience the local culture. Although smaller than its neighbors, Holly Hill's charm lies in its simplicity and the warm welcome you'll receive as you explore its unique shops and natural beauty.

Things to do in and around Santee

Santee enchants travelers with its stunning lakeside scenery, rolling hills, and lush forests. Enjoy a day of fishing or tee off at scenic golf courses, then unwind by the water’s edge. Whether you’re boating or hiking through natural trails, this destination offers a perfect blend of relaxation and outdoor fun.

Edisto Memorial GardensOpens in a new window – Discover the beauty of this enchanting flower garden, where vibrant blooms create a picturesque setting. Enjoy leisurely walks along the pathways, taking in the serene atmosphere and the scenic views of the nearby lake.
Taw Caw CreekOpens in a new window – Spend a relaxing day at Taw Caw Creek, a tranquil lake perfect for fishing, kayaking, or simply soaking up the sun. The calm waters and surrounding nature provide the ideal backdrop for a peaceful getaway.
St. George United Methodist ChurchOpens in a new window – Visit the historic St. George United Methodist Church, where you can appreciate the architectural charm and learn about the community's rich heritage. It's a lovely spot to reflect and enjoy the serene environment.
Jennie J McMahan LibraryOpens in a new window – Stop by the Jennie J McMahan Library, a welcoming space filled with books and resources. Whether you want to catch up on a good read or find information about the local area, this library is a great community hub.
Santee State ParkOpens in a new window – Explore the natural wonders of Santee State Park, a national park that offers a variety of outdoor activities. Hike through scenic trails, enjoy a picnic by the lake, or participate in birdwatching to experience the area's rich wildlife.

4 tips for savvy savings when booking a hotel in Santee

Book for the cheapest times: The most affordable time to visit Santee is during January, February, and December, when hotel prices are typically lower. For those looking to explore the area's historical landmarks and cultural attractions, a stay of at least 1 to 2 days is recommended. This budget-friendly timeframe allows visitors to enjoy the local dining scene, play a round of golf, and experience the friendliness of the community. Additionally, you can indulge in fresh seafood, sip coffee at cozy cafes, enjoy family-friendly activities by the lake, and embark on delightful excursions—all great value for money while on a budget.
Look for last-minute deals on Hotels.com: To uncover potential savings on hotels in Santee, explore the DealsOpens in a new window and Last-Minute DealsOpens in a new window sections on Hotels.com, where you may discover discounted rates as your travel date approaches. Travelers often highlight top hotels in Santee, making it easier to find accommodations that suit your needs. Consider enabling email alerts or push notifications to stay updated on special promotions. Additionally, the Smart ShoppingOpens in a new window feature in the app allows you to compare hotel prices and amenities, helping you choose from our best options. With these tools, you're more likely to book a great last-minute getaway.
Be flexible with dates: Prices can fluctuate based on factors like the hotel's location, star rating, and the time of year, so being flexible with your travel dates may help you find a better deal on your stay in Santee. If you're interested in unique accommodations, boutique hotels can provide a more personalized experience and may offer better value. When you book through Hotels.com, we'll inform you if the price for your chosen dates is above or below the average. If the price is on the higher end, we may suggest alternative dates that could be more budget-friendly.
Consider your location: Hotels near the city center usually tend to be more expensive, but thanks to Santee's great public transportation options, you might discover a more affordable independent hotel a bit farther away that’s still conveniently connected. For those interested in exploring alternative, less crowded neighborhoods or even lesser-known nearby towns, there’s often excellent value to be found. Opting for these alternative locations could provide a more authentic experience while being easier on your budget.

Best time to go to Santee

Santee experiences its lowest average temperature in January, at 47.3°F (8.5°C), while July is the hottest month, with an average temperature of 81.5°F (27.5°C). August is typically the wettest month. If you’re looking to soak up the lively atmosphere in Santee, March, April, and July are the peak months to visit, bustling with fellow travelers. During this peak period, the weather is mostly sunny, with light rainfall. However, if you prefer a more relaxed experience, October to December are perfect for a quieter getaway, marked by light rainfall and mostly sunny conditions.

Hotels in Santee

Free cancellation options if plans change

Unlock travel rewards with One Key

Save more with Member Prices

Check prices for these dates

Where to stay in Santee?

Baymont by Wyndham Santee

Hampton Inn Santee-I-95

Fairfield Inn & Suites by Marriott Santee

Best Western Plus Santee Inn

Tru By Hilton Santee

Holiday Inn Santee by IHG

Comfort Inn & Suites Santee

Travelodge by Wyndham Santee

Ramada by Wyndham Santee I-95

Red Roof Inn Santee

Super 8 by Wyndham Santee/I-95

Quality Inn & Suites Santee I-95

Econo Lodge Santee

Spark by Hilton Orangeburg

Days Inn by Wyndham St George

SureStay Hotel by Best Western Manning

Tru by Hilton Orangeburg

Fairfield Inn by Marriott Orangeburg

Peach Tree Inn

Hampton Inn Manning

Get last-minute hotel deals in Santee and save more

Best Western Plus Santee Inn

Best Western Plus Santee Inn

Best Western Plus Santee Inn

Check out pet-friendly hotels in Santee

Baymont by Wyndham Santee

You may also like hotels with pools in Santee

Fairfield Inn & Suites by Marriott Santee

Go beyond your typical stay in Santee

When is the best time to visit Santee?

Price trends for hotels in Santee

Typical weather for Santee

Top landmarks in Santee

Santee State Park

Learn more about Santee

Check out reviews of Santee hotels guests love

Hampton Inn Santee-I-95

Frequently asked questions

Find out more about Santee

Santee: Where Tranquil Waters Meet Scenic Wonders

Discover great hotels near Santee

Where to stay near Santee

Things to do in and around Santee

4 tips for savvy savings when booking a hotel in Santee

Best time to go to Santee

Keep exploring